short term outcome of saffron supplementation in patients with age-related macular degeneration: a double-blind, placebo-controlled, randomized trial
Authors
abstract
in modern pharmacological medicine, saffron is used for various purposes due to its antioxidant effect. this study evaluated retinal function after treatment with saffron supplementation during a follow-up period of 6 months to provide further insight into the efficacy and safety considerations of this treatment. sixty patients with wet or dry age-related macular degeneration (amd) were randomly assigned to oral saffron 30 mg/d or placebo supplementation for 6 months. optical coherence tomography (oct), electroretinography (erg), fluorescein angiography (fa), and visual acuity (va) testing were recorded at baseline, 3 months, and 6 months after treatment. the main outcome measures were oct, erg amplitude, and implicit time. six months after treatment, no statistically significant decrease in oct resultswas observed between the groups with dry amd (p=0.282). however, there was a statistically significant increase in erg results between thegroups at 3 months (p=0.027). in addition, there was a statistically significant decrease in oct results between groups with wet amd atfollow-up (p=0.05). finally, there was a statistically significant increase in erg findings between the groups with wet amd at 3 months (p=0.01), but these changes decreased after 6 months (p=0.213). in conclusion, daily supplementation with 30 mg of saffron for 6 months may induce a mid-term, significant improvement in retinal function in patients with amd.
similar resources
Short-term Outcomes of Saffron Supplementation in Patients with Age-related Macular Degeneration: A Double-blind, Placebo-controlled, Randomized Trial
In modern pharmacological medicine, saffron is used for various purposes due to its antioxidant effect. This study evaluated retinal function after treatment with saffron supplementation during a follow-up period of 6 months to provide further insight into the efficacy and safety considerations of this treatment. Sixty patients with wet or dry age-related macular degeneration (AMD) were randoml...
full textLow Dose, Short-Term Iron Supplementation in Female Blood Donors of Childbearing Age: a Randomized, Double-Masked, Placebo-Controlled Study
: Iron supplementation for blood donors is a controversial concept. However, to maintain regular blood donors, as a source of blood supply, the present paradigm is not appropriate and dose not prevent harms to blood donors. Methods: A randomized, double-masked, placebo-controlled study, was conducted by enrolling 95 female regular blood donors of childbearing age (18-49 years). The participants...
full textEffect of Memantine on Positive Sign in Patients with Schizophrenia and Schizoaffective Disorders: A Randomized Double Blind Placebo Controlled Trial
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with an...
full textEffect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial
Objective: Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated. Materials and Methods: Thirteen patients suffering from liver metastases who r...
full textEffect of Crocus sativus (Saffron) on Cervical Ripening and Progress of Labor in Primiparous Term Women: A Randomized Double-Blind Placebo-Controlled Trial
Background: Saffron is a perennial plant native to Iran which has been traditionally prescribed to facilitate labor. We aimed to investigate the effect of Crocus sativus (Saffron) on cervical ripening and progress of labor in a sample of primiparous term Iranian women. Materials and Methods: </stro...
full textEffects of Vitamin D Supplementation on Semen Quality and Reproductive Hormones in Patients with Asthenozoospermia: A Randomized Double-Blind Placebo-Controlled Clinical Trial
Background: Animal models and observational studies have suggested a favorable role of vitamin D in male reproduction. However, randomized clinical trials investigating the effect of vitamin D supplementation on male fertility are limited. Therefore, this study aimed to examine the effect of vitamin D supplementation on semen quality, reproductive hormones, and anthropometric measurements in vi...
full textMy Resources
Save resource for easier access later
Journal title:
medical hypothesis, discovery and innovation ophthalmology journalجلد ۵، شماره ۱، صفحات ۰-۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023